Fig. 5
From: NRXN1α+/- is associated with increased excitability in ASD iPSC-derived neurons
The expression of VGKCs and glutamatergic synapse are significantly dysregulated in NRXN1a+/- ASD neurons. A Significantly disturbed VGKCs (in back circle) were identified by “Molecular Function (GO)” group with their relative expression level expressed in TPM B. C Networks clustered by Cytoscape program with proteins associated with glutamatergic synapse in black circle (FDR = 0.003) from KEGG pathway (STRING KEGG pathway). D RNASeq data showing relative mRNA expression (in TMP) of the glutamatergic pathway members which were significantly dysregulated in NRXN1a+/- neurons