Table 2 Fluorescence intensity of Aβ1-42 in the GFP-HEK293Tand OATP1B1-GFP-HEK293T cells when the cells were treated with different concentration of Aβ1-42 during the different incubation time (n = 3)
From: Uptake of Aβ by OATPs might be a new pathophysiological mechanism of Alzheimer disease
Aβ1-42 0 μM | Aβ1-42 0.4 μM | Aβ1-42 1 μM | Aβ1-42 2.5 μM | |||||
|---|---|---|---|---|---|---|---|---|
NC | OATP1B1 | NC | OATP1B1 | NC | OATP1B1 | NC | OATP1B1 | |
24 h | 4162 ± 336 | 3943 ± 167 | 4386 ± 63 | 4316 ± 52 | 4316 ± 107 | 95484 ± 20582 | 25148 ± 7713 | 60935 ± 4789 |
48 h | 3980 ± 145 | 4100 ± 566 | 4333 ± 19 | 4356 ± 74 | 4440 ± 323 | 58629 ± 12127 | 51704 ± 9795 | 139172 ± 18360 |
72 h | 4115 ± 225 | 4233 ± 562 | 4335 ± 52 | 38803 ± 2597 | 16363 ± 8540 | 126123 ± 21186 | 68502 ± 19324 | 166943 ± 20123 |