Fig. 4

Cytokine profiles reflect concurrent skin/brain inflammation, with prior emergence of Th2 inflammation in skin (cf. Table 1). A–D Emergence of elevated TNFα, IFNγ, IL-13 and IL-17A in 1-day-old VPA- vs. vehicle (Veh)-exposed murine skin and brain; B, E–F higher levels of th-2 cytokines (IL-4, IL-5, IL-13) in 1-day old skin vs brain of VPA-exposed mice; G increased TSLP in skin, with absence of this pro-th2 cytokine in the brains of VPA-exposed mice