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Fig. 1 | BMC Neuroscience

Fig. 1

From: Behavioral sensitization induced by methamphetamine causes differential alterations in gene expression and histone acetylation of the prefrontal cortex in rats

Fig. 1

METH-induced behavioral sensitization. a Schematic of the behavioral sensitization training. b Total or time-dependent changes in the locomotion of rats with METH-induced behavioral sensitization within 60 min. Animals were injected once daily with METH (5 mg/kg, s.c.) followed by 7 days of withdrawal, and challenge was induced by a single METH (1.0 mg/kg, s.c.) injection. Data are presented as the means ± SEM of n = 8 rats per group. ***P < 0.001 and *P < 0.05 compared with the NS-NS group. #P < 0.05 compared with the NS-METH group. One-way ANOVA followed by Tukey’s post hoc test. NS: 0.9% saline. METH: methamphetamine

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BMC Neuroscience

ISSN: 1471-2202

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