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Table 2 Effect of genotype (WT v Per2−/−) on the CRFR1 mRNA expression in the pituitary following a 20 min restraint

From:  Knockout of the circadian gene, Per2, disrupts corticosterone secretion and results in depressive‐like behaviors and deficits in startle responses

  WT Per2−/−
0 min 1.1 ± 0.2 0.6 ± 0.2
20 min 1.2 ± 0.3 1.2 ± 0.2
40 min 1.2 ± 0.4 1.0 ± 0.4
60 min 1.1 ± 0.2 1.2 ± 0.3
120 min 1.0 ± 0.2 1.1 ± 0.3
  1. Measurements were taken before restraint (0 min), immediately following restraint (20 min) and 40, 60, and 120 min from the onset of restraint. There were no differences between Per2−/− and WT mice in CRFR1 mRNA expression levels (n = 5–7)