Diazepam and ethanol differently modulate neuronal activity in organotypic cortical cultures

BMC Neuroscience

Table 2 p-Values of the Kolmogorov–Smirnov test evaluating possible differences in the distribution of AP to LFP-phase

FREQ (Hz)	CNT vs. DZP 15 µM	CNT vs. DZP 30 µM	DZP 15 µM vs. DZP 30 µM	CNT vs. EtOH 30 mM	CNT vs. EtOH 60 mM	EtOH 30 mM vs. EtOH 60 mM
0–2	0.7409	0.2461	0.4615	0.0105	0.2461	0.1713
2–4	0.0484	0.0105	0.0018	0.7409	0.2461	0.4615
4–6	0.0009	0.0005	0	0.3427	0.006	0.006
6–8	0.0484	0.0033	0.0001	0.0484	0.3427	0.006
8–10	0.018	0.0002	0	0.1158	0.2461	0.0033
10–12	0.1713	0	0	0.4615	0.1158	0.0033
12–14	0.5982	0	0.0009	0.9561	0.1713	0.1158
14–16	0.3427	0	0.0033	0.8685	0.1158	0.1158

Diazepam (left columns) causes a concentration-dependent change towards a less uniform distribution, i.e., the AP are occurring at a higher rate at the same LFP phase. Ethanol in contrast (right columns) had a weaker, opposite effect towards a more uniform distribution of AP to LFP-phase. Significant differences are indicated as italic p-values

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