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Fig. 5 | BMC Neuroscience

Fig. 5

From: Altered activity in the nucleus raphe magnus underlies cortical hyperexcitability and facilitates trigeminal nociception in a rat model of medication overuse headache

Fig. 5

Effect of inhibiting the NRM on NTG-evoked Fos-IR in the TNC. a Photomicrograph shows patterns of c-Fos-immunoreactivity (Fos-IR) in four experimental groups (scale bar 100 µm in each section and 50 µm in the inset). b Scatterplots comparing the number of Fos-IR cells in four experimental groups. Chronic treatment with acetaminophen increased the number of nitroglycerin (NTG)-evoked Fos-IR neurons in the TNC. Microinjection of muscimol into the NRM did not alter the number of NTG-evoked Fos-IR neurons in the saline-treated vehicle-control and acetaminophen-treated rats

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