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Table 1 Detailed description of items forming the modified neurological severity score (mNSS)

From: The role of PI3K-mediated AMPA receptor changes in post-conditioning of propofol in brain protection

Motor tests  
 Raising rat by tail (normal = 0, maximum = 3) (3)
 Flexion of forelimb 1
 Flexion of hindlimb 1
 Head moved > 10 degree limb vertical axis within 30 s 1
Placing rat on floor (normal = 0, maximum = 3) (3)
 Normal walk 0
 Inability to walk straight 1
 Circling toward the paretic side 2
 Falling down to paretic side 3
Sensory tests (normal = 0, maximum = 2) (2)
 Placing test (visual and tactile test) 1
 Proprioceptive test (deep sensation, pushing paw against table edge to stimulate limb muscles) 1
Beam balance tests (normal = 0, maximum = 6) (6)
 Balance with steady posture 0
 Grasps side of beam 1
 Huging beam and 1 limb falling down from beam 2
 Huging beam and 2 limbs falling down from beam, or spins on beam (> 60 s) 3
 Attempting to balance on beam but falling of (> 40 s) 4
 Attempting to balance on beam but falling of (> 20 s) 5
 Falling of; no attempt to balance or hang on the beam (< 20 s) 6
Reflex absence and abnormal movements (normal = 0, maximum = 4) (4)
 Pinna reflex (head shaken when auditory meatus is touched) 1
 Corneal reflex (eyes blink when cornea is lightly touched with cotton) 1
 Startle reflex (motor response to brief noise from clapping hands) 1
 Seizures, myoclonus, myodystony 1
Maximum points (18)
  1. One point is given for an absent reflex tested or for the animal’s inability to perform a task: 1–6 mild injury, 7–12 moderate injury, and 13–18 severe injury