Fig. 1

Closed head injury mouse model. The experimental timeline began with a 50 g weight dropped 80 cm onto the right side between the ear and eye followed by treatment with the nanocoffee compound initiated 30 min after injury and administered again 3- and 7-days post-injury. As shown, behavioral tests were performed 7, 14, and 23 days post-injury. Protein analysis was performed on brains collected 14 days post-injury. At 30 days post-injury, brains were collected and analyzed via Golgi stain