Fig. 4
From: Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson’s disease model
DAF-2 is involved in the protection role of dopamine neurons in PD. a The expression of BZ555 egIs1 [dat-1p::GFP] was similar as the expression in daf-2(e1370) mutants. The scale bar and magnification of left panel is 50 μm, 200; The scale bar and magnification of right panel is 25 μm, 400, respectively. b Quantification of dat-1p::GFP was no changed in wild type and daf-2(e1370) mutant animals. c daf-2 mutants were more resistant to the injury of 6-OHDA treatment. The scale bar and magnification of left panel is 50 μm, 200; The scale bar and magnification of right panel is 25 μm, 400, respectively. d Quantification of dat-1p::GFP animals was induced than that of daf-2(e1370) mutants treated with 6-OHDA. e DAF-2 is not required for the accumulation of α-synuclein. (The scale bar and magnification of left panel is 200 μm, 40; The scale bar and magnification of right panel is 100 μm, 100). f Quantification of α-synuclein in wild type was consistent with that in daf-2(e1370) mutant animals. The statistical differences were analyzed using t-test, ns P ≥ 0.05; *P < 0.05; **P < 0.01; ***P < 0.001