Fig. 2

Effects of CIS on mechanical and thermal nociception in uninjured rats. A transient reduction in sensitivity to mechanical stimulus was observed in stressed rats at week 3 and week 4 during exposure to chronic intermittent stress. ** = P < 0.01 indicates significant difference between NS and S groups (a). After cessation of stress exposure the mechanical threshold was comparable between NS and S groups (P > 0.05) (b). Thermal threshold between NS and S was not significantly altered during stress session (c) or in post-stress period (P > 0.05) (d). NS non-stress, S stress. n = 18/group. Data is represented as mean ± SEM