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Fig. 8 | BMC Neuroscience

Fig. 8

From: PKCε phosphorylation regulates the mitochondrial translocation of ATF2 in ischemia-induced neurodegeneration

Fig. 8

A proposed model for PKCε phosphorylation of ATF2 during ischemia-induced neurodegeneration. Phosphorylation of ATF2 by PKCε at Thr-52 is required for the nuclear localization of ATF2. The expression level of PKCε is attenuated in response to global cerebral ischemia, resulting in translocation of ATF2 to the mitochondria and degeneration of neuronal cells

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BMC Neuroscience

ISSN: 1471-2202

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