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Fig. 1 | BMC Neuroscience

Fig. 1

From: Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation

Fig. 1

Timeline of the experiments. Mice were unilaterally lesioned with 6-hydroxydopamine (6-OHDA) injections into the medial forebrain bundle. Levodopa (6 mg/kg) together with benserazide (1.5 mg/kg) was administered s.c. daily (Mon–Fri). The α7 nicotinic receptor partial agonist AZD0328 was administered s.c. at three escalating doses for 1 week (Mon–Fri) per dose. Nicotine was administered continuously in saccharin-sweetened drinking water, with the concentration gradually increased to 300 µg/ml over 2 weeks. Severity of levodopa-induced dyskinesia was assessed from videos recorded weekly at the indicated time points

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BMC Neuroscience

ISSN: 1471-2202

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