Fig. 4
Modulation of GP-cell based on two control parameters. As shown to the upper right, cells are chained for integrating series of stimuli. Each cell can be driven by a Contextual (C) input from its predecessor in the chain, and can also be activated by a stimulus (S). Depending on its Excitability (vertical axis) and the ratio R between its contextual weight w5ht and its stimulus weight wne (horizontal axis), a given cell runs in one of five operating modes: Inhibited, Restricted, Context-driven, Stimulus-driven, and Free. The right-most red crosses stand for cells of forward-looking channels, implementing strong anticipation in the context-driven area. The blue left arrows reflect the R decrease during an offline cycle (Fig. 3), towards the restricted mode that ensures proper growth of memory paths. However, this encoding process may start as soon as the threshold θE is reached. In case of w5ht noise, θE can be set up to θ*E in order to restore the proper sequence of offline phases, at the expense of the connectivity. The red dots indicate (R, E) values that entail impaired encoding; the yellow dot meets proper encoding, provided low E (high Da) towards the bottom of the “Restricted” area. This setting of GP parameters is consistent with the pattern of monoamines assumed in Fig. 1 to underlie autism, namely low 5-HT and high DA metabolisms