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Table 5 Comparison of K1 values (2 compartment model) between 18F-florbetaben and 18F-flutemetamol in AD transgenic group

From: Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer’s disease with PET imaging agents 18F-flutemetamol and 18F-florbetaben

Group Rstr Lstr Cor Rhip Lhip Thal Crbl
18F-flutemetamol
 Mean + SD 7.380 ± 1.032 7.331 ± 1.103 6.861 ± 1.331 6.972 ± 1.303 7.3 ± 0.900 7.841 ± 0.240 7.400 ± 1.410
 Median (IQR) 7.98 (6.95–8) 8 (6.84–8) 7.52 (5.85–7.95) 7.29 (6.38–8) 7.92 (6.31–8) 7.95 (7.61–8) 8 (7.66–8)
18F-florbetaben
 Mean + SD 4.991 ± 3.091 4.581 ± 2.960 3.561 ± 2.160 4.182 ± 2.160 4.802 ± 2.160 4.891 ± 2.160 5.060 ± 2.160
 Median (IQR) 4.9 (1–8) 4.51 (1–8) 3.92 (1–4.63) 3.84 (1–7.63) 4.78 (1–7.95) 4.88 (1.18–8) 5.84 (1.65–7.61)
p-value 0.128 0.053 0.011** 0.073 0.128 0.038** 0.073
  1. Cor cortex, Crbl cerebellum, Rhip Rt. hippocampus, Lhip Lt. hippocampus, Thala Thalamus, Rstr Rt. striatum, Lstr Lt. striatum, ** p < 0.05 considered as significant