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Table 5 Comparison of K1 values (2 compartment model) between 18F-florbetaben and 18F-flutemetamol in AD transgenic group

From: Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer’s disease with PET imaging agents 18F-flutemetamol and 18F-florbetaben

Group

Rstr

Lstr

Cor

Rhip

Lhip

Thal

Crbl

18F-flutemetamol

 Mean + SD

7.380 ± 1.032

7.331 ± 1.103

6.861 ± 1.331

6.972 ± 1.303

7.3 ± 0.900

7.841 ± 0.240

7.400 ± 1.410

 Median (IQR)

7.98 (6.95–8)

8 (6.84–8)

7.52 (5.85–7.95)

7.29 (6.38–8)

7.92 (6.31–8)

7.95 (7.61–8)

8 (7.66–8)

18F-florbetaben

 Mean + SD

4.991 ± 3.091

4.581 ± 2.960

3.561 ± 2.160

4.182 ± 2.160

4.802 ± 2.160

4.891 ± 2.160

5.060 ± 2.160

 Median (IQR)

4.9 (1–8)

4.51 (1–8)

3.92 (1–4.63)

3.84 (1–7.63)

4.78 (1–7.95)

4.88 (1.18–8)

5.84 (1.65–7.61)

p-value

0.128

0.053

0.011**

0.073

0.128

0.038**

0.073

  1. Cor cortex, Crbl cerebellum, Rhip Rt. hippocampus, Lhip Lt. hippocampus, Thala Thalamus, Rstr Rt. striatum, Lstr Lt. striatum, ** p < 0.05 considered as significant