Fig. 9
From: Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice
Densities of PV neurons and WFA-positive PNNs in juvenile-stressed or control mice. The region-specific patterns of PV neuron density (a–c) and WFA-positive PNN density (d–f) in individual regions are shown. The region-specific pattern of the percentage of PV neurons enveloped by WFA-positive PNNs (g–i) and the percentage of WFA-positive PNNs that contain PV (j–l) are shown in the individual regions, hippocampus (CA1, CA3, and DG) (a, d, g, j), prefrontal cortex (dAC, PL, and IL) (b, e, h, k), motor cortex (c, f, i, l) of control or stress mice. All data are presented as the mean ± SEM. *Significant difference from control mice (p < 0.05). The p values indicate two-way ANOVA by Bonferroni t test. Abbreviations are the same as those in Fig. 8. a Hippocampus; group: F1,66 = 0.086, region: F2,66 = 6.449, group × region: F2,66 = 0.111. CA1: p = 0.6254. CA3: p = 0.8485. DG: p = 0.8626, b prefrontal cortex; group: F1,132 = 0.126, region: F5,132 = 48.755, group × region: F5,132 = 0.966. dAC L2/3: p = 0.3783. dAC L5/6: p = 0.4354. PL L2/3: p = 0.9115. PL L5/6: p = 0.2392. IL L2/3: p = 0.9986. IL L5/6: p = 0.1444, c M1; group: F1,44 = 1.140, region: F1,44 = 0.997, group × region: F1,44 = 0.002. M1 L2/3: p = 0.4744. M1 L5/6: p = 0.4345, d hippocampus; group: F1,66 = 0.134, region: F2,66 = 11.937, group × region: F2,66 = 0.618. CA1: p = 0.09717. CA3: p = 0.2794. DG: p = 0.6745, e prefrontal cortex; group: F1,132 = 0.895, region: F5,132 = 16.458, group × region: F5,132 = 0.476. dAC L2/3: p = 0.4839. dAC L5/6: p = 0.3845. PL L2/3: p = 0.9320. PL L5/6: p = 0.3263. IL L2/3: p = 0.4270. IL L5/6: p = 0.5232, f M1; group: F1,44 = 3.048, region: F1,44 = 0.636, group × region: F1,44 = 0.144. M1 L2/3: p = 0.3391. M1 L5/6: p = 0.1401, g hippocampus; group: F1,66 = 0.145, region: F2,66 = 1.550, group × region: F2,66 = 0.730. CA1: p = 0.6958. CA3: p = 0.2359. DG: p = 0.8866, h prefrontal cortex; group: F1,114 = 0.132, region: F5,114 = 9.911, group × region: F5,114 = 6.183. dAC L2/3: p = 0.9590. dAC L5/6: p = 0.2913. PL L2/3: p = 0.3957. PL L5/6: p = 0.1294. IL L5/6: p = 0.4050, i M1; group: F1,44 = 3.446, region: F1,44 = 0.060, group × region: F1,44 = 0.6514. M1 L2/3: p = 0.1093. M1 L5/6: p = 0.3271, j hippocampus; group: F1,66 = 0.012, region: F2,66 = 3.619, group × region: F2,66 = 0.617. CA1: p = 0.4328. CA3: p = 0.8622. DG: p = 0.4441, k prefrontal cortex; group: F1,116 = 0.886, region: F5,116 = 17.793, group × region: F5,116 = 0.905. dAC L2/3: p = 0.9922. dAC L5/6: p = 0.2344. PL L2/3: p = 0.9398. PL L5/6: p = 0.1568. IL L2/3: p = 0.3948. IL L5/6: p = 0.2722, l M1; group: F1,44 = 6.832, region: F1,44 = 3.364, group × region: F1,44 = 0.049. M1 L2/3: p = 0.0977. M1 L5/6: p = 0.0512