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Table 2 Neuropsychological function and hormone levels in patients at baseline and after administered donepezil for 24–26 weeks (n = 21)

From: Higher levels of thyroxine may predict a favorable response to donepezil treatment in patients with Alzheimer disease: a prospective, case–control study

Variables (mean ± SD) Baseline Follow up F(1,18)a/F(1, 20) p value η 2p (%)
MMSE scoresa 16.1 ± 5.4 17.1 ± 5.2 0.25 .624 1.4
Cortisol (μg/dl) 10.2 ± 2.9 10.6 ± 1.8 0.45 .511 2.2
Thyrotropin (mIU/l) 1.4 ± 0.9 1.4 ± 1.0 0.42 .523 2.1
Total T3 (ng/dl) 85.5 ± 8.6 81.4 ± 10.1 7.57 .012 27.4
Free T3 (pg/ml) 2.3 ± 0.3 2.2 ± 0.3 1.52 .233 7
Total T4 (μg/dl) 6.4 ± 1.0 5.7 ± 1.0 7.12 .015 26.3
Free T4 (ng/dl) 1.0 ± 0.1 1.0 ± 0.1 0.07 .800 0.3
  1. MMSE Mini–Mental State Examination
  2. aAge and years of education as covariates