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Table 2 Regulated genes involved in inflammation in all experimental groups classified by gene ontology

From: Neuroprotective dobutamine treatment upregulates superoxide dismutase 3, anti-oxidant and survival genes and attenuates genes mediating inflammation

Inflammation related genes Ctrl versus Ctrl D Ctrl versus LPS Ctrl versus OGD OGD versus OGD D LPS versus LPS D LPS OGD versus LPS D OGD
Ptgs2, Prostaglandin-endoperoxide synthase 2 11.9 42.8     0.4
Csf2rb1, Colony stimulating factor 2 receptor, beta 1 8.7      
Cd14, CD14 antigen 8.4     2.7  
Tgm2, Transglutaminase 2, C polypeptide 7.2 7.4     0.4
Bcl3, B-cell leukemia/lymphoma 3 6.9      
Socs3, Suppressor of cytokine signaling 3 5.8 11.7 2.6    
Cd86, CD86 antigen 4.2   2.2    
Sbno2, Strawberry notch homolog 2 (Drosophila) 3.4      
Clcf1, Cardiotrophin-like cytokine factor 1 3.2      
Litaf, LPS-induced TN factor 3.0 2.7     
Edg3, Endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 2.9      
Fcgr3, Fc receptor, IgG, low affinity III 2.6      
Osmr, Oncostatin M receptor 2.5 5.1     
C5ar1, Complement component 5a receptor 1 2.4      
Il4ra, Interleukin 4 receptor, alpha 2.4     3.1  
Pde4d, Phosphodiesterase 4D, cAMP specific 2.4      
Ccrl2, Chemokine (C–C motif) receptor-like 2 2.3 62.3     0.3
P2rx7, Purinergic receptor P2X, ligand-gated ion channel, 7 2.3      
Tnfrsf1b, Tumor necrosis factor receptor superfamily, member 1b 2.3 5.0     0.4
Cxcr7, Chemokine (C-X-C motif) receptor 7 2.2     3.6  
Tgfbi, Transforming growth factor, beta induced 2.1      
Fbxl8, F-box and leucine-rich repeat protein 8 0.5      
Iigp1, Interferon inducible GTPase 1 0.5 131.2    0.4 0.1
March1, Membrane-associated ring finger (C3HC4) 1 0.5      
Peli2, Pellino 2 0.5 0.4     
Prrx1, Paired related homeobox 1 0.5      
Cmtm7, CKLF-like MARVEL transmembrane domain containing 7 0.4      
Ifit2, Interferon-induced protein with tetratricopeptide repeats 2 0.4 20.5    0.3 0.1
Pilra, Paired immunoglobin-like type 2 receptor alpha 0.4      2.3
Selpl, Selectin, platelet (p-selectin) ligand 0.4      
Ccl3, Chemokine (C–C motif) ligand 3 0.3 280.8    0.1  
Cx3cr1, Chemokine (C-X3-C) receptor 1 0.3     0.4  
F3, Coagulation factor III 0.3      
Cxcl10, Chemokine (C-X-C motif) ligand 10 0.2 126.4   2.5   0.3
Tnf, Tumor necrosis factor   625.9 3.2   0.1  
Ifit1, Interferon-induced protein with tetratricopeptide repeats 1   143.8     0.3
Mpa2 l, Macrophage activation 2 like   120.1    0.5 0.3
Tnfaip3, Tumor necrosis factor, alpha-induced protein 3   111.8    0.4 0.5
Tnfaip2, Tumor necrosis factor, alpha-induced protein 2   102.3     0.4
Igtp, Interferon gamma induced GTPase   96.0    0.4 0.2
Irf7, Interferon regulatory factor 7   73.2     0.2
Tyki, Thymidylate kinase family LPS-inducible member   72.0    0.4 0.1
Ptx3, Pentraxin related gene   60.0     
Slfn5, Schlafen 5   37.9     0.4
Slfn2, Schlafen 2   37.2     0.5
Irf1, Interferon regulatory factor 1   37.1   2.3 0.4 0.5
Tap1, Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)   36.3     
Tlr2, Toll-like receptor 2   32.0     
Ripk2, Receptor (TNFRSF)-interacting serine-threonine kinase 2   23.9     
Slfn9, Schlafen 9   21.4     0.3
Ly6a, Lymphocyte antigen 6 complex, locus A   16.4     0.1
Ifi35, Interferon-induced protein 35   16.1     0.3
Ifi202b, Interferon activated gene 202B   14.1     0.4
Tap2, Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)   13.0     0.4
Samhd1, SAM domain and HD domain, 1   11.4     0.4
Myd88, Myeloid differentiation primary response gene 88   9.6     
Ifi44, Interferon-induced protein 44   8.8     0.3
Plaur, Plasminogen activator, urokinase receptor   7.5     
Tnip1, TNFAIP3 interacting protein 1   7.5     
Rnf125, Ring finger protein 125   7.1     
Ifi203, Interferon activated gene 203   5.8     0.3
H2-M3, Histocompatibility 2, M region locus 3   5.7     0.4
Nmi, N-myc (and STAT) interactor   5.0     0.4
Irak2, Interleukin-1 receptor-associated kinase 2   4.7     
Tapbp, TAP binding protein   4.5     0.4
Il17ra, Interleukin 17 receptor A   4.4     
Tapbpl, TAP binding protein-like   4.2     
Tcirg1, T-cell, immune regulator 1   3.7     
Plek, Pleckstrin   3.3     
Irf2, Interferon regulatory factor 2   3.2     
Plau, Plasminogen activator, urokinase   3.1     
Ifitm3, Interferon induced transmembrane protein 3   2.9     0.4
Ifrg15, Interferon alpha responsive gene   2.9     
Tnfrsf14, Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)   2.8     0.4
Irf5, Interferon regulatory factor 5   2.7     
Tnfrsf12a, Tumor necrosis factor receptor superfamily, member 12a   2.7     
C3, Complement component 3   2.5   2.2   
Ifitm1, Interferon induced transmembrane protein 1   2.5     
Il18 bp, Interleukin 18 binding protein   2.5     0.4
Tcrb-V13, T-cell receptor beta, variable 13   2.4     
Traf2, Tnf receptor-associated factor 2   2.4     
Cxcl12, Chemokine (C-X-C motif) ligand 12   2.3     
Traf5, Tnf receptor-associated factor 5   2.3     0.5
Lcp1, Lymphocyte cytosolic protein 1   2.2     
Socs2, Suppressor of cytokine signaling 2   2.2     
Igsf10, Immunoglobulin superfamily, member 10   2.1     
Ptgir, Prostaglandin I receptor (IP)   2.1     
Peli1, Pellino 1   2.0     
Tnfsf12, Tumor necrosis factor (ligand) superfamily, member 12   0.5     
Ptgs1, Prostaglandin-endoperoxide synthase 1   0.4     
Ptgds2, Prostaglandin D2 synthase 2, hematopoietic   0.3     
Cxcr4, Chemokine (C-X-C motif) receptor 4   0.2     
Hmha1, Histocompatibility (minor) HA-1   0.1     
Ccl4, Chemokine (C–C motif) ligand 4   329.0    0.3 0.4
Trem2, Triggering receptor expressed on myeloid cells 2   0.4     2.5
Lgals3, Lectin, galactose binding, soluble 3    3.5    0.3
Aebp1 (gUuMeU):AE binding protein 1    2.2    
Trib1, Tribbles homolog 1 (Drosophila)    2.2    0.5
Gbp6, Guanylate binding protein 6     2.7   0.4
Cd72, CD72 antigen     0.5   
Inhba. Inhibin beta-A      5.4  
Dusp14. Dual specificity phosphatase 14      2.6  
Itga1. Integrin alpha 1      2.6  
Csrp2. Cysteine and glycine-rich protein 2      2.5  
Csrp2. Cysteine and glycine-rich protein 2      2.4  
Ampd3. AMP deaminase 3      0.5  
C1r. Complement component 1. r subcomponent      0.5 0.3
C3ar1. Complement component 3a receptor 1      0.5  
Cd274. CD274 antigen      0.5 0.5
H2-D1. Histocompatibility 2. D region locus 1      0.5 0.1
Tgfb3. Transforming growth factor. beta 3      0.5  
Tgfbr2. Transforming growth factor. beta receptor II      0.5  
Tlr4. Toll-like receptor 4      0.5  
Gvin1. GTPase. very large interferon inducible 1      0.4 0.3
Csf1. Colony stimulating factor 1      0.3 0.4
S100a4, S100 calcium binding protein A4       2.1
Csf1r, Colony stimulating factor 1 receptor       2.0
Fcgr2b, Fc receptor, IgG, low affinity IIb       0.5
Scarf2, Scavenger receptor class F, member 2       0.5
Stat2, Signal transducer and activator of transcription 2       0.5
Gimap5, GTPase, IMAP family member 5       0.4
H2-D4, Histocompatibility 2, D region locus 4       0.4
H2-K1, Histocompatibility 2, K1, K region       0.4
Trafd1, TRAF type zinc finger domain containing 1       0.4
Trex1, Three prime repair exonuclease 1       0.4
B2 m, Beta-2 microglobulin       0.3
Casp1, Caspase 1       0.3
Fcgr1, Fc receptor, IgG, high affinity I       0.3
Irgm, Immunity-related GTPase family, M       0.3
Stat1, Signal transducer and activator of transcription 1       0.3
Bst2, Bone marrow stromal cell antigen 2       0.1
Ly6c, Lymphocyte antigen 6 complex, locus C       0.1
Ly6e, Lymphocyte antigen 6 complex, locus E       0.1
  1. D dobutamine, LPS lipopolysaccharide, OGD oxygen–glucose-deprivation