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Table 2 Regulated genes involved in inflammation in all experimental groups classified by gene ontology

From: Neuroprotective dobutamine treatment upregulates superoxide dismutase 3, anti-oxidant and survival genes and attenuates genes mediating inflammation

Inflammation related genes

Ctrl versus Ctrl D

Ctrl versus LPS

Ctrl versus OGD

OGD versus OGD D

LPS versus LPS D

LPS OGD versus LPS D OGD

Ptgs2, Prostaglandin-endoperoxide synthase 2

11.9

42.8

   

0.4

Csf2rb1, Colony stimulating factor 2 receptor, beta 1

8.7

     

Cd14, CD14 antigen

8.4

   

2.7

 

Tgm2, Transglutaminase 2, C polypeptide

7.2

7.4

   

0.4

Bcl3, B-cell leukemia/lymphoma 3

6.9

     

Socs3, Suppressor of cytokine signaling 3

5.8

11.7

2.6

   

Cd86, CD86 antigen

4.2

 

2.2

   

Sbno2, Strawberry notch homolog 2 (Drosophila)

3.4

     

Clcf1, Cardiotrophin-like cytokine factor 1

3.2

     

Litaf, LPS-induced TN factor

3.0

2.7

    

Edg3, Endothelial differentiation, sphingolipid G-protein-coupled receptor, 3

2.9

     

Fcgr3, Fc receptor, IgG, low affinity III

2.6

     

Osmr, Oncostatin M receptor

2.5

5.1

    

C5ar1, Complement component 5a receptor 1

2.4

     

Il4ra, Interleukin 4 receptor, alpha

2.4

   

3.1

 

Pde4d, Phosphodiesterase 4D, cAMP specific

2.4

     

Ccrl2, Chemokine (C–C motif) receptor-like 2

2.3

62.3

   

0.3

P2rx7, Purinergic receptor P2X, ligand-gated ion channel, 7

2.3

     

Tnfrsf1b, Tumor necrosis factor receptor superfamily, member 1b

2.3

5.0

   

0.4

Cxcr7, Chemokine (C-X-C motif) receptor 7

2.2

   

3.6

 

Tgfbi, Transforming growth factor, beta induced

2.1

     

Fbxl8, F-box and leucine-rich repeat protein 8

0.5

     

Iigp1, Interferon inducible GTPase 1

0.5

131.2

  

0.4

0.1

March1, Membrane-associated ring finger (C3HC4) 1

0.5

     

Peli2, Pellino 2

0.5

0.4

    

Prrx1, Paired related homeobox 1

0.5

     

Cmtm7, CKLF-like MARVEL transmembrane domain containing 7

0.4

     

Ifit2, Interferon-induced protein with tetratricopeptide repeats 2

0.4

20.5

  

0.3

0.1

Pilra, Paired immunoglobin-like type 2 receptor alpha

0.4

    

2.3

Selpl, Selectin, platelet (p-selectin) ligand

0.4

     

Ccl3, Chemokine (C–C motif) ligand 3

0.3

280.8

  

0.1

 

Cx3cr1, Chemokine (C-X3-C) receptor 1

0.3

   

0.4

 

F3, Coagulation factor III

0.3

     

Cxcl10, Chemokine (C-X-C motif) ligand 10

0.2

126.4

 

2.5

 

0.3

Tnf, Tumor necrosis factor

 

625.9

3.2

 

0.1

 

Ifit1, Interferon-induced protein with tetratricopeptide repeats 1

 

143.8

   

0.3

Mpa2 l, Macrophage activation 2 like

 

120.1

  

0.5

0.3

Tnfaip3, Tumor necrosis factor, alpha-induced protein 3

 

111.8

  

0.4

0.5

Tnfaip2, Tumor necrosis factor, alpha-induced protein 2

 

102.3

   

0.4

Igtp, Interferon gamma induced GTPase

 

96.0

  

0.4

0.2

Irf7, Interferon regulatory factor 7

 

73.2

   

0.2

Tyki, Thymidylate kinase family LPS-inducible member

 

72.0

  

0.4

0.1

Ptx3, Pentraxin related gene

 

60.0

    

Slfn5, Schlafen 5

 

37.9

   

0.4

Slfn2, Schlafen 2

 

37.2

   

0.5

Irf1, Interferon regulatory factor 1

 

37.1

 

2.3

0.4

0.5

Tap1, Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

 

36.3

    

Tlr2, Toll-like receptor 2

 

32.0

    

Ripk2, Receptor (TNFRSF)-interacting serine-threonine kinase 2

 

23.9

    

Slfn9, Schlafen 9

 

21.4

   

0.3

Ly6a, Lymphocyte antigen 6 complex, locus A

 

16.4

   

0.1

Ifi35, Interferon-induced protein 35

 

16.1

   

0.3

Ifi202b, Interferon activated gene 202B

 

14.1

   

0.4

Tap2, Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

 

13.0

   

0.4

Samhd1, SAM domain and HD domain, 1

 

11.4

   

0.4

Myd88, Myeloid differentiation primary response gene 88

 

9.6

    

Ifi44, Interferon-induced protein 44

 

8.8

   

0.3

Plaur, Plasminogen activator, urokinase receptor

 

7.5

    

Tnip1, TNFAIP3 interacting protein 1

 

7.5

    

Rnf125, Ring finger protein 125

 

7.1

    

Ifi203, Interferon activated gene 203

 

5.8

   

0.3

H2-M3, Histocompatibility 2, M region locus 3

 

5.7

   

0.4

Nmi, N-myc (and STAT) interactor

 

5.0

   

0.4

Irak2, Interleukin-1 receptor-associated kinase 2

 

4.7

    

Tapbp, TAP binding protein

 

4.5

   

0.4

Il17ra, Interleukin 17 receptor A

 

4.4

    

Tapbpl, TAP binding protein-like

 

4.2

    

Tcirg1, T-cell, immune regulator 1

 

3.7

    

Plek, Pleckstrin

 

3.3

    

Irf2, Interferon regulatory factor 2

 

3.2

    

Plau, Plasminogen activator, urokinase

 

3.1

    

Ifitm3, Interferon induced transmembrane protein 3

 

2.9

   

0.4

Ifrg15, Interferon alpha responsive gene

 

2.9

    

Tnfrsf14, Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

 

2.8

   

0.4

Irf5, Interferon regulatory factor 5

 

2.7

    

Tnfrsf12a, Tumor necrosis factor receptor superfamily, member 12a

 

2.7

    

C3, Complement component 3

 

2.5

 

2.2

  

Ifitm1, Interferon induced transmembrane protein 1

 

2.5

    

Il18 bp, Interleukin 18 binding protein

 

2.5

   

0.4

Tcrb-V13, T-cell receptor beta, variable 13

 

2.4

    

Traf2, Tnf receptor-associated factor 2

 

2.4

    

Cxcl12, Chemokine (C-X-C motif) ligand 12

 

2.3

    

Traf5, Tnf receptor-associated factor 5

 

2.3

   

0.5

Lcp1, Lymphocyte cytosolic protein 1

 

2.2

    

Socs2, Suppressor of cytokine signaling 2

 

2.2

    

Igsf10, Immunoglobulin superfamily, member 10

 

2.1

    

Ptgir, Prostaglandin I receptor (IP)

 

2.1

    

Peli1, Pellino 1

 

2.0

    

Tnfsf12, Tumor necrosis factor (ligand) superfamily, member 12

 

0.5

    

Ptgs1, Prostaglandin-endoperoxide synthase 1

 

0.4

    

Ptgds2, Prostaglandin D2 synthase 2, hematopoietic

 

0.3

    

Cxcr4, Chemokine (C-X-C motif) receptor 4

 

0.2

    

Hmha1, Histocompatibility (minor) HA-1

 

0.1

    

Ccl4, Chemokine (C–C motif) ligand 4

 

329.0

  

0.3

0.4

Trem2, Triggering receptor expressed on myeloid cells 2

 

0.4

   

2.5

Lgals3, Lectin, galactose binding, soluble 3

  

3.5

  

0.3

Aebp1 (gUuMeU):AE binding protein 1

  

2.2

   

Trib1, Tribbles homolog 1 (Drosophila)

  

2.2

  

0.5

Gbp6, Guanylate binding protein 6

   

2.7

 

0.4

Cd72, CD72 antigen

   

0.5

  

Inhba. Inhibin beta-A

    

5.4

 

Dusp14. Dual specificity phosphatase 14

    

2.6

 

Itga1. Integrin alpha 1

    

2.6

 

Csrp2. Cysteine and glycine-rich protein 2

    

2.5

 

Csrp2. Cysteine and glycine-rich protein 2

    

2.4

 

Ampd3. AMP deaminase 3

    

0.5

 

C1r. Complement component 1. r subcomponent

    

0.5

0.3

C3ar1. Complement component 3a receptor 1

    

0.5

 

Cd274. CD274 antigen

    

0.5

0.5

H2-D1. Histocompatibility 2. D region locus 1

    

0.5

0.1

Tgfb3. Transforming growth factor. beta 3

    

0.5

 

Tgfbr2. Transforming growth factor. beta receptor II

    

0.5

 

Tlr4. Toll-like receptor 4

    

0.5

 

Gvin1. GTPase. very large interferon inducible 1

    

0.4

0.3

Csf1. Colony stimulating factor 1

    

0.3

0.4

S100a4, S100 calcium binding protein A4

     

2.1

Csf1r, Colony stimulating factor 1 receptor

     

2.0

Fcgr2b, Fc receptor, IgG, low affinity IIb

     

0.5

Scarf2, Scavenger receptor class F, member 2

     

0.5

Stat2, Signal transducer and activator of transcription 2

     

0.5

Gimap5, GTPase, IMAP family member 5

     

0.4

H2-D4, Histocompatibility 2, D region locus 4

     

0.4

H2-K1, Histocompatibility 2, K1, K region

     

0.4

Trafd1, TRAF type zinc finger domain containing 1

     

0.4

Trex1, Three prime repair exonuclease 1

     

0.4

B2 m, Beta-2 microglobulin

     

0.3

Casp1, Caspase 1

     

0.3

Fcgr1, Fc receptor, IgG, high affinity I

     

0.3

Irgm, Immunity-related GTPase family, M

     

0.3

Stat1, Signal transducer and activator of transcription 1

     

0.3

Bst2, Bone marrow stromal cell antigen 2

     

0.1

Ly6c, Lymphocyte antigen 6 complex, locus C

     

0.1

Ly6e, Lymphocyte antigen 6 complex, locus E

     

0.1

  1. D dobutamine, LPS lipopolysaccharide, OGD oxygen–glucose-deprivation
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BMC Neuroscience

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