Fig. 11

Cur and SLCP treatments reduce neuroinflammation in DG area of hippocampus in 5xFAD mice. The 5xFAD mice were treated with Cur or SLCP for 2- or 5-days, sacrificed, and their brain sections were collected and immunolabeled for Iba-1 and GFAP. The number of Iba-1-IR (a, b) and GFAP-IR (a, c) were significantly reduced (*p < 0.05; **p < 0.01) in the DG area of hippocampus in comparison to untreated 5xFAD mice. Further reduction was observed after 5-, relative to 2-, days of treatment in the amount for both GFAP and Iba-1 labeling (b, c). Scale bar indicates 250 µm and is applicable to other images