Fig. 1

Tg6799 mice showed behavioral improvement after intraventricular (icv) infusion of clusterin peptide D-[113–122]. Tg6799 mice received nothing (non-treat), saline (NS) or clusterin peptide D-[113–122] via icv infusion for 2 weeks as indicated. Acquisition trial was performed four times a day for 4 consecutive days. Swimming time (a) and distance (c) to arrive at the platform was recorded. Non-treat and NS mice showed no improvement in swimming distance in comparison to clusterin treat group, and clusterin treat group exhibited less time-to-platform. On the following day a probe test was performed and clusterin treat group showed more time spent in the goal quadrant (b) as opposed to non-treat and NS mice. Data is presented as mean ± S.E.M. 8 months of age, n = 10 per group. *p < 0.05, one-way ANOVA followed by Turkey post hoc test