Skip to main content

Table 4 Matrix effects (mean ± SD) of plasma and brain on analytes (n = 5)

From: A convenient UHPLC-MS/MS method for routine monitoring of plasma and brain levels of nicotine and cotinine as a tool to validate newly developed preclinical smoking model in mouse

Concentration (ng/mL)

Matrix factor (%)

Plasma

 Nicotine

  LQC

9

80.32 ± 2.46

  MQC

75

75.96 ± 18.97

  HQC

150

77.37 ± 10.84

 Cotinine

  LQC

9

90.00 ± 0.30

  MQC

225

78.47 ± 4.13

  HQC

450

87.08 ± 11.61

Brain

  

 Nicotine

  LQC

9

92.61 ± 5.12

  MQC

40

91.37 ± 9.13

  HQC

80

90.54 ± 7.29

 Cotinine

  LQC

9

86.64 ± 2.38

  MQC

40

89.65 ± 8.49

  HQC

80

91.92 ± 5.16

Back to article page

BMC Neuroscience

ISSN: 1471-2202

Contact us