Fig. 5

Effects of combinations of ion channel inhibitors on additional indicators of oxidative stress. Mean ± SEM intensity above an arbitrarily set threshold for a 8-hydroxy-2′deoxyguanosine (8OHDG); b Carboxymethyl lysine (CML); and mean ± SEM area above an arbitrarily set threshold for c 3-nitrotyrosine (3NT); or d manganese superoxide dismutase (MnSOD) immunoreactivity were quantified at 3 days following partial optic nerve transection, in ventral optic nerve of normal, or injured vehicle or treated animals. Significant differences relative to vehicle are indicated by *p ≤ 0.05. Representative images of e 8OHDG, f CML, g 3NT and h MnSOD immunoreactivity in normal and injured vehicle or inhibitor treated ventral nerve, 3 days following partial transection; scale bars = 50 μm