Fig. 3
From: Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents
Merged mouse and rat network (mapped to human proteins). The colored genes were used to build the analysis/network of protein–protein interaction partners. The squares with colored borders represent targets from the rat network, and colored circles indicate targets from the mouse network. The arrowheads indicate the common targets found in mouse and rat networks. p = 0.0000808, Wilcoxon, mouse data, enrichment of regulated biomarkers. p = 0.00000217, Wilcoxon, rat data, enrichment of regulated biomarkers. The scale denotes p values for significance of differential expression, ranging from green (p = 0) to dark red (p = 1). Targets with colored borders represent the rat p value, and center colors indicate mouse p values. Gray represents targets in which no qPCR data were obtained