White matter damage and systemic inflammation in Parkinson’s disease

BMC Neuroscience

Table 2 Regions showing fractional anisotropy differences among patients with PD and control subjects

MNI Atlas coordinates			Voxel size	White matter tract	Near cortical area	FA, mean ± SD		T_max	Diffusivity values (PD-NC) (×10⁻⁶mm²/s)
x	y	z	Voxel size	White matter tract	Near cortical area	Controls	PD	T_max	MD	AD	RD
Decreased FA in PD versus controls
−25	−63	31	4183	Left inferior longitudinal fasciculus	Left parietal lobe	0.475 ± 0.030	0.445 ± 0.029	6.17	24.83*	1.23	36.64*
26	−60	32	3962	Right superior longitudinal fasciculus	Right parietal lobe	0.467 ± 0.022	0.439 ± 0.026	4.67	24.6*	2.62	35.58*
40	−59	−5	745	Right inferior longitudinal fasciculus	Right occipital lobe	0.430 ± 0.035	0.399 ± 0.038	4.53	15.39	−16.43	31.3*
−41	−21	53	702	Left superior longitudinal fasciculus	Left postcentral gyrus	0.384 ± 0.033	0.361 ± 0.046	4.28	36.41	17.13	46.06
−34	−53	−43	642	Left cerebellum	Left cerebellum	0.270 ± 0.016	0.260 ± 0.017	4.06	21.08*	16.04	23.61*
−38	−17	−1	1423	Left inferior fronto-occipital fasciculus	Left insula	0.429 ± 0.020	0.413 ± 0.023	3.97	26.74*	14.44	32.88*

Location of maximum effect (uncorrected P < 0.001, cluster size >610) was shown in the Montreal Neurological Institute (MNI) space
Group FA mean values in each cluster are presented as mean ± standard deviation
The FA, MD, AD, and RD values in each region of interest were further compared between the two groups by analysis of covariance after controlling for age, sex, and education
FA fractional anisotropy, MD mean diffusivity, AD axial diffusivity, RD radial diffusivity, PD Parkinson’s disease
* P < 0.05 with the Bonferroni correction, accounting for multiple ROI comparisons

ISSN: 1471-2202