Fig. 4

Transiently enhanced cocaine locomotor sensitization in DAT-Cre mice. a KalSR^DAT-KO and control (KalSR^CKO) mice displayed similar locomotor responses to saline and to the first two injections of cocaine (C1, C2). KalSR^DAT-KO mice exhibited significantly increased ambulation on C3 (p = 0.002) and on C5 (p = 0.048) (RM-ANOVA). There were no genotypic differences on days C6 and C7 (N = 19 KalSR^CKO, N = 20 KalSR^DAT-KO, males only). b KalSR^Drd1a-KO and control (KalSR^CKO) mice displayed similar locomotor responses to saline and cocaine (N = 7 KalSR^CKO control, N = 6 KalSR^Drd1a-KO, males only). c Kal7^Drd2-KO and control (Kal7^CKO) mice displayed similar locomotor responses to saline and cocaine (N = 21 Kal7^CKO control, N = 11 Kal7^Drd2-KO, males only). Differences in ambulatory counts between sets of control mice were influenced by different testing venues during animal tower renovation. All testing for a single genotype was performed in one location