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Fig. 4 | BMC Neuroscience

Fig. 4

From: Using Kalirin conditional knockout mice to distinguish its role in dopamine receptor mediated behaviors

Fig. 4

Transiently enhanced cocaine locomotor sensitization in DAT-Cre mice. a KalSRDAT-KO and control (KalSRCKO) mice displayed similar locomotor responses to saline and to the first two injections of cocaine (C1, C2). KalSRDAT-KO mice exhibited significantly increased ambulation on C3 (p = 0.002) and on C5 (p = 0.048) (RM-ANOVA). There were no genotypic differences on days C6 and C7 (N = 19 KalSRCKO, N = 20 KalSRDAT-KO, males only). b KalSRDrd1a-KO and control (KalSRCKO) mice displayed similar locomotor responses to saline and cocaine (N = 7 KalSRCKO control, N = 6 KalSRDrd1a-KO, males only). c Kal7Drd2-KO and control (Kal7CKO) mice displayed similar locomotor responses to saline and cocaine (N = 21 Kal7CKO control, N = 11 Kal7Drd2-KO, males only). Differences in ambulatory counts between sets of control mice were influenced by different testing venues during animal tower renovation. All testing for a single genotype was performed in one location

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