| Escitalopram | Paroxetine | ||
---|---|---|---|---|
F | P | F | P | |
mTORC1 | ||||
 Drug | 7.498 | 0.013 | 8.198 | 0.010 |
 Stress | 8.402 | 0.009 | 10.616 | 0.004 |
 Drug × stress | 10.662 | 0.004 | 6.990 | 0.016 |
Downstream effectors of mTORC1 | ||||
 4E-BP-1 | ||||
  Drug | 13.592 | 0.001 | 12.403 | 0.002 |
  Stress | 20.717 | <0.001 | 28.600 | <0.001 |
  Drug × stress | 9.579 | 0.006 | 11.679 | 0.003 |
 p70S6 K | ||||
  Drug | 8.868 | 0.007 | 5.866 | 0.025 |
  Stress | 17.816 | <0.001 | 17.947 | <0.001 |
  Drug × stress | 10.815 | 0.004 | 7.900 | 0.011 |
 eIF4B | ||||
  Drug | 8.157 | 0.010 | 6.669 | 0.018 |
  Stress | 19.425 | <0.001 | 16.753 | 0.001 |
  Drug × stress | 5.919 | 0.024 | 8.980 | 0.007 |
 S6 | ||||
  Drug | 4.194 | 0.050 | 6.878 | 0.016 |
  Stress | 12.204 | 0.002 | 12.117 | 0.002 |
  Drug × stress | 7.238 | 0.014 | 14.918 | 0.001 |
Upstream activators of mTORC1 | ||||
 Akt | ||||
  Drug | 21.744 | <0.001 | 18.971 | <0.001 |
  Stress | 47.192 | <0.001 | 51.327 | <0.001 |
  Drug × stress | 17.682 | <0.001 | 13.422 | 0.002 |
 ERK | ||||
  Drug | 17.581 | <0.001 | 21.123 | <0.001 |
  Stress | 14.075 | 0.001 | 25.637 | <0.001 |
  Drug × stress | 21.477 | <0.001 | 14.569 | 0.001 |