Fig. 2
From: TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis
Selection of generic TDP-43 binding detection phages. Binding of selected phages with homogenized ALS, FTD and healthy control (HT) brain tissue from the motor cortex was tested in indirect phage ELISAs using three of the potential detection phages and a commercial anti-TDP-43 antibody. The TDP-43 binding patterns with a TDPM1, b TDPM2, c TDPM3 and d the commercial anti-TDP-43 antibody were all similar. TDPM1’s reactivity with all three groups seemed the closest to the commercial anti-TDP-43 antibody. Binding signals were represented relative to FTD. Bound phages were detected with an anti-M13-HRP antibody in these indirect ELISAs