Fig. 1

Degeneration of axons in the dorsal column of mice intoxicated with paclitaxel. Images are cross-sectioned semithin (1 µm) plastic sections of spinal cords stained for toluidine blue. a Control vehicle-treated (cremophor) spinal cord at lumbar level. No degenerated axons are observed. b Paclitaxel treated spinal cord. Degenerated myelin profiles are present in dorsal column of thoracic level where ascending central branches axons of DRG neurons reside. c Paclitaxel treated spinal cord. Degenerated myelin profiles are present in dorsal column of lumbar level where ascending central branches axons of DRG neurons reside. d High magnification of a showing no degenerated axons. e High magnification of b showing degenerated myelin profiles (arrows). f High magnification of c showing degenerated myelin profiles (arrows). Scale bar in c = 50 μm and applies to a–c. Scale bar in f = 10 μm and applies to d–f