Fig. 6
From: Developmental interneuron subtype deficits after targeted loss of Arx
Neuropeptide Y immunohistochemistry at 2 postnatal time points revels alteration of expression at P14, but not adult. The top row (P14 cortex, A–A″) demonstrates a reduction of NPY positive cells in the cortex between the control and both Arx −/y ;Dlx5/6 CIG and Arx +/−female animals. The second row, (P14 hippocampus, B–B″) illustrates a similar difference in NPY cells in the hippocampus as was found in the cortex. In the adult, there were no significant difference found between Arx +/−female and wildtype in either the cortex (third row; C–C′) or hippocampus (last row, D–D′). E, F Displays the quantification of NPY positive cell numbers from P14 (E) and adult (F) measuring the percent change from control in both the cortex and hippocampus. LV lateral ventricle, WM white matter, Cx developing cortex, Hip Hippocampus. L1 cortical layer 1, L2/3 cortical layers 2 and 3, L6 cortical layer 6, DG dentate gyrus, CA1–CA3 Cornus Ammonis regions 3 and 1