Fig. 2
From: Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia
The OPLS-DA score plots and loading plots derived from the 600 MHz 1H NMR spectra of cortex samples (a, a′) and hippocampus samples (b, b′) extracted from the mice in female sham group (filled square) and female experimental group (triangle). Each group contains six samples (n = 6). The values of Q2 parameter, which were > 0.4, indicated that the established OPLS-DA models were valid. Those metabolites with the value of variable importance in the projection (VIP) bigger than 1 and the absolute value of correlation coefficient |r| greater than the cutoff value of 0.576 were defined to be the discriminative metabolites for group clustering. The discriminative metabolites with the value of correlation coefficient r > 0.576 indicated that their levels increased upon the global ischemic attack. And those discriminative metabolites with the value of correlation coefficient r < −0.576 indicated that their levels decreased upon the global ischemic attack