Fig. 4

CD11b immunohistochemistry to study microglial activation after QA striatal lesion. In the non-lesioned side CD11b-immunopositive cells were easily detectable at high magnification both in control (a) and PLP-α-syn mice (b). There was intense microglia activation following QA injection on the lesioned side in both controls (c) and PLP-α-syn mice (d). Statistical analysis with two-way ANOVA showed comparable intensity of microglial activation in control and PLP-α-syn mice as measured by CD11b optical density (e). Data are presented as mean ± SEM. ***p < 0.001. OD optical density