Fig. 2
![Fig. 2](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12868-015-0226-7/MediaObjects/12868_2015_226_Fig2_HTML.gif)
Temporal change in abnormal tissue lesion volumes compared with ST-ISODATA calculated abnormal tissue signature volumes. Abnormal tissue lesion volumes (whole markers) and ST-ISODATA assigned abnormal tissue signature volumes (open markers) in the four macaques. Largest tissue lesion volumes represented regions of ‘Maximal Lesion’ and were used for parameter optimization of ST-ISODATA. pMCAo2 died before 408 h follow-up, the 240 h was used as follow-up instead. tMCAo2 240 h T2 was not available