Fig. 7
Effects of CBL on learning memory in the water maze in 3R Tau tg mice. a Water maze testing presented as distance traveled to find the platform, respectively in the 3–6 month group. During the cued portion of the test both the vehicle and CBL treated non-tg and 3R tau tg mice performed as expected. However during the hidden portion of the test, the vehicle treated 3R tau tg mice went a farther distance to find the platform compared to the non-tg, CBL prevented these effects. b At day 8, during the probe portion of the test (with platform removed) memory retention was evaluated in the 3–6 month group. c In the 3–6 month group, probe test with the visual platform confirmed that no visual alterations were detected. d Water maze testing presented as distance traveled to find the platform in the 6–9 month group. During the cued portion of the test both the vehicle and CBL treated non-tg and 3R tau tg mice performed as expected. However during the hidden portion of the test, the vehicle treated 3R Tau tg mice went a farther distance to find the platform compared to the non-tg. e At day 8, during the probe portion of the test (with platform removed) memory retention was evaluated in the 6–9 month group. f In the 6–9 month group, probe test with the visual platform showed visual alterations in the 3R tau tg group. For analysis, N = 10 non-tg and N = 10 3R Tau tg mice from each age and treatment group. *P < 0.05 when compared to non-tg control using one way ANOVA with Dunnet’s post hoc test. # P < 0.05 when compared to vehicle-treated tg mice control using one way ANOVA with Dunnet’s post hoc test