Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain

Ignacio, Cherry; Hicks, Steven D.; Burke, Patrick; Lewis, Lambert; Szombathyne-Meszaros, Zsuzsa; Middleton, Frank A.

doi:10.1186/s12868-015-0195-x

Table 4 Variables correlated with Tiers A or B miRNAs in AUD subjects (p < 0.05)

From: Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain

miRNA	Variable	AUD			Ctrl			All
miRNA	Variable	R	P-value	N	R	P-value	N	R	P-value
In Tiers A and B
miR-660-5p	Drinking days last month	0.626	0.030	6
mir-421	Drinking days last week	0.482	0.020	12
mir-320b-1	Drinks per drinking day	0.599	0.007	15
mir-320b-2	Drinks per drinking day	0.934	0.002	15
mir-24-1	Gamma-glutamyl transferase	0.448	0.034	16	−0.558	0.276	9	0.312	0.084
mir-92b	Gamma-glutamyl transferase	0.691	0.005	17	0.306	0.329	10	0.173	0.350
mir-421	Gamma-glutamyl transferase	0.476	0.022	14	−0.396	0.404	9	−0.024	0.914
mir-671	Gamma-glutamyl transferase	0.594	0.043	16	−0.016	0.968	9	0.538	0.001
mir-1976	Gamma-glutamyl transferase	0.474	0.023	9	0.595	0.091	7	0.509	0.017
mir-3615	Gamma-glutamyl transferase	0.476	0.028	17	−0.002	0.997	10	0.046	0.817
mir-24-1	Left inferior frontal triangular gyrus	0.548	0.006	16	0.547	0.068	9	0.060	0.768
mir-136	Left inferior frontal triangular gyrus	0.567	0.005	7	0.211	0.708	5	−0.108	0.753
mir-1976	Left inferior frontal triangular gyrus	0.531	0.009	9	−0.069	0.887	7	−0.327	0.307
mir-320b-2	Left ventral diencephalon	0.930	0.002	17	−0.606	0.213	10	−0.229	0.311
miR-301a-3p	Letter fluency score	0.732	0.025	6	0.797	0.055	4	0.480	0.077
mir-320b-2	Letter fluency score	0.771	0.032	17	−0.396	0.371	9	−0.467	0.065
miR-660-5p	Letter fluency score	0.602	0.040	6	0.700	0.114	4	0.753	0.001
mir-30a	Right anterior collateral transverse sulcus	0.467	0.026	17	0.080	0.819	10	−0.240	0.292
miR-301a-3p	Right anterior collateral transverse sulcus	0.845	0.005	6	0.652	0.152	5	0.728	0.002
mir-92b	Right cingulomarginal sulcus	0.547	0.037	17	0.209	0.524	10	0.390	0.019
mir-24-1	Right pars opercularis	0.441	0.037	16	−0.009	0.983	9	−0.099	0.655
mir-136	Right pars opercularis	0.447	0.034	7	−0.556	0.496	5	−0.287	0.443

Pearson correlation analysis of miRNA expression levels in AUD subjects reveal significant relationships between specific miRNA expression levels and other medical, drinking and neuroimaging variables that were significantly different in AUD subjects
R Pearson correlation coefficient, N number of pairs used in the calculation

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ISSN: 1471-2202

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