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Table 4 Variables correlated with Tiers A or B miRNAs in AUD subjects (p < 0.05)

From: Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain

miRNA Variable AUD Ctrl All
R P-value N R P-value N R P-value
In Tiers A and B
 miR-660-5p Drinking days last month 0.626 0.030 6      
 mir-421 Drinking days last week 0.482 0.020 12      
 mir-320b-1 Drinks per drinking day 0.599 0.007 15      
 mir-320b-2 Drinks per drinking day 0.934 0.002 15      
 mir-24-1 Gamma-glutamyl transferase 0.448 0.034 16 −0.558 0.276 9 0.312 0.084
 mir-92b Gamma-glutamyl transferase 0.691 0.005 17 0.306 0.329 10 0.173 0.350
 mir-421 Gamma-glutamyl transferase 0.476 0.022 14 −0.396 0.404 9 −0.024 0.914
 mir-671 Gamma-glutamyl transferase 0.594 0.043 16 −0.016 0.968 9 0.538 0.001
 mir-1976 Gamma-glutamyl transferase 0.474 0.023 9 0.595 0.091 7 0.509 0.017
 mir-3615 Gamma-glutamyl transferase 0.476 0.028 17 −0.002 0.997 10 0.046 0.817
 mir-24-1 Left inferior frontal triangular gyrus 0.548 0.006 16 0.547 0.068 9 0.060 0.768
 mir-136 Left inferior frontal triangular gyrus 0.567 0.005 7 0.211 0.708 5 −0.108 0.753
 mir-1976 Left inferior frontal triangular gyrus 0.531 0.009 9 −0.069 0.887 7 −0.327 0.307
 mir-320b-2 Left ventral diencephalon 0.930 0.002 17 −0.606 0.213 10 −0.229 0.311
 miR-301a-3p Letter fluency score 0.732 0.025 6 0.797 0.055 4 0.480 0.077
 mir-320b-2 Letter fluency score 0.771 0.032 17 −0.396 0.371 9 −0.467 0.065
 miR-660-5p Letter fluency score 0.602 0.040 6 0.700 0.114 4 0.753 0.001
 mir-30a Right anterior collateral transverse sulcus 0.467 0.026 17 0.080 0.819 10 −0.240 0.292
 miR-301a-3p Right anterior collateral transverse sulcus 0.845 0.005 6 0.652 0.152 5 0.728 0.002
 mir-92b Right cingulomarginal sulcus 0.547 0.037 17 0.209 0.524 10 0.390 0.019
 mir-24-1 Right pars opercularis 0.441 0.037 16 −0.009 0.983 9 −0.099 0.655
 mir-136 Right pars opercularis 0.447 0.034 7 −0.556 0.496 5 −0.287 0.443
  1. Pearson correlation analysis of miRNA expression levels in AUD subjects reveal significant relationships between specific miRNA expression levels and other medical, drinking and neuroimaging variables that were significantly different in AUD subjects
  2. R Pearson correlation coefficient, N number of pairs used in the calculation