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Table 2 Medical, neuropsychological, and neuroimaging variables with significant changes in AUD subjects

From: Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain

Variable % Δ AUD T-test p-value Equality of variance
Medical
 Gamma-glutamyl transferasea 84.9 0.040 0.001
Neuropsychological
 Letter fluency scorea −21.8 0.017 0.035
Normalized neuroimaging volumes
 Cerebrospinal fluid 31.7 0.005
 Anterior corpus callosum −14.6 0.008
 Left temporal superiorlateral gyrus −10.4 0.010
 Left ventral diencephalon 6.9 0.011
 Left central sulcus 16.7 0.012
 Left cingulomarginal sulcus −11.9 0.015
 Right temporal superiorlateral gyrus −10.7 0.019
 Right pars orbitalis white matter 13.3 0.024
 Left inferior occipital gyrus and sulcus −14.9 0.026
 Left superior temporal cortex −7.0 0.027
 Right anterior collateral transverse sulcus −15.4 0.032
 Left Brodmann’s area 3a 12.7 0.032
 Left superior frontal cortex 8.0 0.038
 3rd ventricle 22.3 0.039
 Right intraparietal and posterior transverse sulcus −10.3 0.041
 Right pars opercularis −13.2 0.043
 Right superior parietal cortex −8.4 0.043
 Left inferior frontal triangular gyrus −16.0 0.044
 Right inferior parietal cortex −7.7 0.049
 Right cingulomarginal sulcus −8.4 0.050
  1. Comparison of various clinical and imaging parameters between AUD and control subjects. Neuroimaging measurements were normalized to whole brain size to correct for overall brain shrinkage before calculating  % changes relative to values from controls
  2. aIndicates variables determined to have unequal variances using the Fisher’s F test that were examined for differences between groups using the Welch’s T-test. All other variables were evaluated using the Student’s T-test