Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain

Table 2 Medical, neuropsychological, and neuroimaging variables with significant changes in AUD subjects

Variable	% Δ AUD	T-test p-value	Equality of variance
Medical
Gamma-glutamyl transferase^a	84.9	0.040	0.001
Neuropsychological
Letter fluency score^a	−21.8	0.017	0.035
Normalized neuroimaging volumes
Cerebrospinal fluid	31.7	0.005	–
Anterior corpus callosum	−14.6	0.008	–
Left temporal superiorlateral gyrus	−10.4	0.010	–
Left ventral diencephalon	6.9	0.011	–
Left central sulcus	16.7	0.012	–
Left cingulomarginal sulcus	−11.9	0.015	–
Right temporal superiorlateral gyrus	−10.7	0.019	–
Right pars orbitalis white matter	13.3	0.024	–
Left inferior occipital gyrus and sulcus	−14.9	0.026	–
Left superior temporal cortex	−7.0	0.027	–
Right anterior collateral transverse sulcus	−15.4	0.032	–
Left Brodmann’s area 3a	12.7	0.032	–
Left superior frontal cortex	8.0	0.038	–
3rd ventricle	22.3	0.039	–
Right intraparietal and posterior transverse sulcus	−10.3	0.041	–
Right pars opercularis	−13.2	0.043	–
Right superior parietal cortex	−8.4	0.043	–
Left inferior frontal triangular gyrus	−16.0	0.044	–
Right inferior parietal cortex	−7.7	0.049	–
Right cingulomarginal sulcus	−8.4	0.050	–

Comparison of various clinical and imaging parameters between AUD and control subjects. Neuroimaging measurements were normalized to whole brain size to correct for overall brain shrinkage before calculating % changes relative to values from controls
^aIndicates variables determined to have unequal variances using the Fisher’s F test that were examined for differences between groups using the Welch’s T-test. All other variables were evaluated using the Student’s T-test

ISSN: 1471-2202