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Fig. 5 | BMC Neuroscience

Fig. 5

From: Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain

Fig. 5

p53 is highly involved in AUD-related miRNA changes. Ingenuity IPA analysis of ethanol up- (red) or down- (green) regulated miRNAs in Tiers A & B show enrichment of molecules implicated in p53-related pathways. Molecular activity prediction shows a general inhibition of this pathway as a result of miRNA expression changes. ADAMTS8 ADAM metallopeptidase with thrombospondin 8, CEP120 centrosomal protein 120, Cg Choriogonadotropin, CHSY3 chondroitin sulfate synthase 3, Gulo gulonolactone L-oxidase, MRPS33 mitochondrial ribosomal protein S33, NPEPL1 aminopeptidase-like 1, PAK1 p-21 protein-activated kinase 1, PNPLA3 patatin-like phospholipase domain-containing protein 3, PROSC proline synthetase, SCYL3 SCY1-like 3, SLC2A8 and 10A3, solute carriers 2A8 and 10A3, TMEM163 transmembrane protein 163, TNF tumor necrosis factor, XKR8 XK, Kell blood group complex subunit-related family 8

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BMC Neuroscience

ISSN: 1471-2202

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