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Figure 7 | BMC Neuroscience

Figure 7

From: Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy

Figure 7

Schematic showing hypothesized nNOS/peroxynitrite-mediated deleterious events and GSNO-mediated targets. IR-induced excitotoxicity and calcium dysregulation cause aberrant nNOS activation, peroxynitrite formation and LKB1/AMPK activation. GSNO treatment of IR blocks the vicious cycle by inhibiting the aberrant activity of nNOS and LKB1/AMPK, leading to neuroprotection and improved neurobehavioral function.

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