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Figure 3 | BMC Neuroscience

Figure 3

From: Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels

Figure 3

Presynaptic localization of CTN-1/α-catulin and DYB-1/dystrobrevin (A) Presynaptic localization of CTN-1/α-catulin is partially dependent on DYB-1/dystrobrevin. The integrated array cimIs8, which drives GFP-tagged CTN (GFP::CTN-1) expression in a subset of DA and DB neurons, was crossed to slo-1 or dyb-1 mutants. The number of puncta within 10 μm in each data point was presented as the mean ± SEM and analyzed by one-way ANOVA Dunett’s multiple comparison (wild-type, n = 20; slo-1, n = 29; dyb-1, n = 20. ***p < 0.001; n.s. p > 0.05). (B) Presynaptic localization of DYB-1/dystrobrevin is independent of CTN-1/α-catulin. The integrated array cimIs15, which drives GFP-tagged DYB (GFP::DYB-1) expression in a subset of DA and DB neurons, was crossed to slo-1 or ctn-1 mutants. The number of puncta within 10 μm in each data point was presented as the mean ± SEM (one-way ANOVA Dunett’s multiple comparison, wild-type, n = 34; slo-1, n = 31; ctn-1, n = 30; n.s. p > 0.05). The scale bar represents 5 μm.

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BMC Neuroscience

ISSN: 1471-2202

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