The effect of adolescent testosterone on hippocampal BDNF and TrkB mRNA expression: relationship with cell proliferation

Table 3 Correlations between Ki67 mRNA expression and BDNF/TrkB transcript mRNA expression within separate rat treatment groups

	Gdx		Intact		Gdx + T		Gdx + DHT		Gdx + E
	r-value	p-value	r-value	p-value	r-value	p-value	r-value	p-value	r-value	p-value
Ki67 vs TrkB-TK+	0.40	0.17	0.96	0.00000025 ^***	0.86	0.00017 ^***	0.655	0.011 ^**	0.77	0.00072 ^***
Ki67 vs TrkB-T1	−0.036	0.90	0.11	0.73	0.56	0.056	0.72	0.0054 ^**	−0.055	0.85
Ki67 vs TrkB-T2	−0.31	0.28	0.077	0.80	0.12	0.69	0.26	0.38	−0.098	0.73
Ki67 vs BDNF I	0.50	0.067	0.79	0.0037 ^**	0.75	0.0046 ^***	0.56	0.047 ^*	0.097	0.74
Ki67 vs BDNF IIA	−0.40	0.16	0.26	0.39	0.43	0.14	0.054	0.86	−0.039	0.89
Ki67 vs BDNF IIC	0.45	0.11	0.93	0.000003 ^***	0.89	0.000040 ^***	0.59	0.025 ^*	0.76	0.0011 ^***
Ki67 vs BDNF III	0.092	0.75	0.79	0.0037 ^**	0.72	0.0052 ^**	0.55	0.041 ^*	0.70	0.0036 ^**
Ki67 vs BDNF IV	0.19	0.52	0.45	0.12	0.47	0.10	0.31	0.29	0.46	0.082
Ki67 vs BDNF VI	−0.016	0.96	0.59	0.035 ^*	0.49	0.090	0.28	0.33	0.18	0.53

The presence of sex steroids (Intact, Gdx + T, Gdx + DHT and Gdx + E2) changed the relationship between Ki67 mRNA expression and expression of TrkB-TK+, BDNF I, BDNF IIC and BDNF III compared to Intact and Gdx + DHT groups. *p < 0.05, **p < 0.01, ***p < 0.001, bold type = p≤0.05.

ISSN: 1471-2202