Loss of CaMKK β or CaMK IV reduced p-CREB levels 6 hours after stroke. A and B, representative Western blots of p-CREB in CaMKK β/CaMK IV KO mice. C and D, quantification of p-CREB expression, n = 2 sham/n = 3 stroke. Data were normalized to corresponding WT sham. #P < 0.05 compared to WT stroke; Data were presented as mean ± SEM.