Figure 2

Loss of CaMKK β/CaMK IV exacerbated stroke infarct volumes and cerebral hemorrhagic transformation (HT) in females. A and E, Infarct volumes in CaMKK β/CaMK IV KO females mice; C and G, Hemoglobin content were higher in CaMKK β/CaMK IV KO females 72 hours after stroke; concentration unit: ug/per hemisphere; B and F, representative brains with cerebral infarcts in CaMKK β/CaMK IV KO females and corresponding controls; D and H, representative brains with cerebral HT in CaMKK β/CaMK IV KO females and corresponding controls; All female mice were ovxed 10 days before MCAO. In figure A and C, n = 7 WT/ n = 9 KO, in figure D and G, n = 8 for each group; ^#p < 0.05: versus WT controls. Student t-test was used to compare means. Data were presented as mean ± SEM.