Effect of membrane property modulations by dopamine on synchronous/asynchronous activity in a network of globus pallidus externus
© Kitano et al; licensee BioMed Central Ltd. 2008
- Published: 11 July 2008
- Firing Rate
- Burst Activity
- Single Compartment Model
- Globus Pallidus Externus
- Input Strength
Subthalamic nuclei (STN) and globus pallidus externus (GPe) are important nuclei for basal ganglia functions since spatio-temporal patterns of neural activity in the nuclei have a close relationship with movement disorders such as Parkinson disease. However, the mechanism of transition between normal tonic activity and pathological rhythmical burst activity with changing dopamine levels has been still unclear. Rebound burst activity of STN neurons, which is induced by strong hyperpolarization, may play a key role for such an activity mode transition. On the other hand, the GPe is a major source of hyperpolarizing input to the STN. Therefore, an understanding of the dynamical properties of a GPe network is gaining importance.
We investigated how synchronous/asynchronous properties of the GPe network were modulated by dopamine. To this end, we first constructed a single compartment model of a GPe neuron, and applied phase response analysis to the model GPe neuron , changing conductances of a persistent sodium channel and an L-type calcium channel, both of which are modulated by dopamine in the striatal spiny neurons .
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- Kuramoto Y: Chemical oscillations, waves, and turbulence. 1984, NewYork: Springer-VerlagView ArticleGoogle Scholar
- Surmeier DJ, Ding J, Day M, Wang Z, Shen W: D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons. TRENDS in Neurosciences. 2007, 30: 228-234. 10.1016/j.tins.2007.03.008.View ArticlePubMedGoogle Scholar
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