- Poster presentation
- Open Access
Synaptic symmetry breaking by spike timing dependent synaptic plasticity
© Shin and Kim; licensee BioMed Central Ltd. 2008
- Published: 11 July 2008
- Animal Model
- Experimental Study
- Brain Region
- Symmetry Breaking
- Synaptic Plasticity
Recent experimental studies have shown that in various brain regions, such as the hippocampus and the neocortex, both the sign and the magnitude of synaptic modification depend on the precise temporal relation of spike timing of two neurons, which is called spike timing dependent synaptic plasticity (STDP). Due to the asymmetry of the critical window of STDP, STDP tends to lead morphologically reciprocal synaptic connections between two neurons into a functionally uni-directional synaptic connection. We study the spontaneous symmetry breaking of bi-directional synaptic connections between two neurons, which leads the synaptic competition in a larger network. We show that STDP is optimized to the symmetry breaking for the experimentally observed time scale range of the critical window.
This article is published under license to BioMed Central Ltd.