Figure 5

Regional and temporal expression of transcription genes. (Left) Venn diagrams of the differentially expressed genes in PS-/-, PS-NA and 4L/PS-NA cerebellum (upper) and cerebrum (lower). The numbers in various regions represent the total of significantly differentially expressed genes in the intersection or complements. For example, 292 genes were significantly differentially expressed in 4L/PS-NA, whereas only 3 genes were shared in PS-/-, PS-NA and 4L/PS-NA cerebellum. Very few genes were shared in three models: Three genes (3*; CEBPD, Efemp1 and Neurod6) in cerebellum and two genes (2*; CEBPD and Man2B1) in cerebrum. Only CEBPD is the common gene in two tissues of three models. There are additional 49 or 16 genes shared by PS-NA or 4L/PS-NA in cerebellum and cerebrum (Atf3, Nfia, etc.). (Right) Expression changes of three shared transcription factors. The expression of CEBPD and Atf3 was increased and Nfia was decreased. Atf3 and Nfia were not altered in PS-/-. Each column presents the fold change at each time point. The dotted lines represent ± 1.5 fold. Time points for PS-NA and 4L/PS-NA are 0 day (white columns), 4 wk (line columns), 12 wk (black columns) and 18 wk (hatch columns); for PS-/- are 0 (white columns), 10 (line columns), 20 (black columns) and 25 (hatch columns) days.