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Table 1 Caspase-3 activity in Neuro2a cells exposed to Hcy.

From: NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells

 

pNa amounts (nmol/h/mg prot)

Control

60 ± 3.3

+ Hcy (250 μM)

142 ± 15.1 **

+ Hcy (250 μM) + SN50 (30 μg/ml)

87 ± 9.5 *

+ Hcy (250 μM) + IRFI 016 (80 μM)

96 ± 7.9 *

+ Hcy (250 μM) + NAC (500 μM)

102 ± 9.2 *

SN50 (30 μg/ml)

53 ± 2.9

IRFI 016 (80 μM)

42 ± 3.4

  1. The evaluation of caspase-3 activity was carried out based on measurements of specific cleavage of DEVD-pNa as described in Materials and methods. Results are mean ± SEM of six experiments. * p < 0.05 and **p < 0.01 significant differences in comparison to control cells.
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BMC Neuroscience

ISSN: 1471-2202

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