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Table 1 Caspase-3 activity in Neuro2a cells exposed to Hcy.

From: NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells

  pNa amounts (nmol/h/mg prot)
Control 60 ± 3.3
+ Hcy (250 μM) 142 ± 15.1 **
+ Hcy (250 μM) + SN50 (30 μg/ml) 87 ± 9.5 *
+ Hcy (250 μM) + IRFI 016 (80 μM) 96 ± 7.9 *
+ Hcy (250 μM) + NAC (500 μM) 102 ± 9.2 *
SN50 (30 μg/ml) 53 ± 2.9
IRFI 016 (80 μM) 42 ± 3.4
  1. The evaluation of caspase-3 activity was carried out based on measurements of specific cleavage of DEVD-pNa as described in Materials and methods. Results are mean ± SEM of six experiments. * p < 0.05 and **p < 0.01 significant differences in comparison to control cells.