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Archived Comments for: Changes in corticospinal excitability and the direction of evoked movements during motor preparation: A TMS study

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  1. The modulation of corticospinal excitability during the foreperiod

    Craig Sinclair, University of Western Australia

    28 July 2008

    I was interested by your findings presented in this paper.

    I found the observation of a significant Precue x Time interaction in the prime mover APB muscle to be interesting. In particular, the fact that the MEP amplitude appeared to decline across the foreperiod when the precued movement was one which maximally engaged the APB muscle (180, 225, or 270 degrees movements) as opposed to when the precued movement was not requiring such strong abduction/flexion (90, 135 degrees movements).

    I wonder if this might reflect a movement specific suppression of MEP amplitude in the prime mover muscle during the foreperiod? If so, do you think that this might involve a different inhibitory mechanism to the more generalized suppression seen in the non-involved FDI muscle regardless of the precued direction?

    Competing interests

    No competing interests