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Table 2 Wheel running did not ameliorate the effects of the HD mutation on body and brain weight at 9 months of age. The HD transgene affected both body weight (P < 0.001) and brain weight (P < 0.001) at 9 months of age, relative to WT littermates. NE: non-enriched (standard housed); RW: running-wheel housed.

From: Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease

  WT HD
  RW NE RW NE
Body weight (grams) 39.70 ± 3.01 32.36 ± 2.57 22.38 ± 1.05 22.54 ± 0.75
Brain weight (grams) 0.54 ± 0.015 0.53 ± 0.008 0.42 ± 0.011 0.42 ± 0.007