Persistent changes in spinal cord gene expression after recovery from inflammatory hyperalgesia: A preliminary study on pain memory

Table 3 Ontologic classification of genes differentially expressed at 28d.

Category	Number of sequences	% of total	p-value
Cadherin-like	13	3.40%	1.30E-14
cell-cell adhesion	18	4.70%	4.10E-07
*Synapse formation*
regulation of cell proliferation	20	5.20%	5.70E-04
neurogenesis	15	3.90%	7.60E-03
morphogenesis	34	8.90%	2.70E-03
neuron differentiation	15	3.90%	2.80E-03
*Apoptosis*
regulation of apoptosis	22	5.80%	1.80E-04
negative regulation of apoptosis	12	3.10%	8.90E-04
*Regulatory pathways*
calcium ion binding	31	8.10%	2.60E-06
ion binding	62	16.30%	5.50E-04
transmission of nerve impulse	20	5.20%	4.90E-04
actin polymerization and/or depolymerization	7	1.80%	2.40E-04
cytoskeleton organization and biogenesis	18	4.70%	1.70E-03
nerve ensheathment	5	1.30%	4.30E-03
*Enzyme*
phosphorylation	39	10.20%	9.50E-04
acetylation	14	3.70%	3.20E-03

Functional analysis of differentially expressed transcript employed DAVID tools (see Methods for detailed description). To calculate background, Affychip has been used. Some transcripts represent in more than one category. Cutoff value for category selection p < 0.05.

ISSN: 1471-2202