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Table 1 Current and Ca2+ responses in the vehicle and AP bursting groups were equivalent.

From: A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity

    vehicle AP bursting p value
Current peak current pA 607 ± 110 585 ± 82 0.83
  peak current density pA/pS 8.49 ± 1.08 9.41 ± 1.00 0.54
  charge transfer nC 31.67 ± 6.60 25.95 ± 4.77 0.49
  τ on s 7.60 ± 1.14 8.21 ± 1.24 0.72
  τ off s 19.64 ± 3.49 16.92 ± 2.76 0.54
  left half width s 31.79 ± 3.73 39.27 ± 3.47 0.16
  right half width s 78.72 ± 13.94 77.15 ± 10.73 0.93
Ca2+ peak Ca2+ nM 600 ± 133 540 ± 121 0.75
  Ca2+ 10 min later nM 270 ± 179 149 ± 51 0.46
  Ca2+ AUC nM.s 211 ± 79 152 ± 38 0.46
  left half width s 147 ± 101 105 ± 55 0.70
  right half width s 287 ± 150 159 ± 34 0.34
  1. Charge transfer and area under the curve (AUC) were calculated from the integral of the trace between the current response onset and return to baseline and between the Ca2+ response onset and a point 10 min later. Current data comes from 9 vehicle and 10 AP bursting neurons of which Ca2+ data was recorded in 5 vehicle and 6 AP bursting cells. All Ca2+ analysis was performed from a somatic region of interest.