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Feedback modulation of intrinsic firing dynamics restores feature detection in electrosensory processing

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Neurons are almost invariably embedded in complex feedback networks. In order to study the feedback regulation of individual neurons and their ability to accurately code sensory information we chose to examine a simple, well understood feedback network. Specifically, we examine here a simple network based on the known neuroanatomical substrates underlying sensory processing in the weakly electric fish Apteronotus leptorhynchus. We consider here a network of 100 biophysically plausible model neurons, embedded in an inhibitory closed loop consisting of GABAA and GABAB mediated conductances. We have shown previously an interaction between the GABAB portion of this inhibitory feedback and the burst dynamics intrinsic to ELL pyramidal cells. By including the intrinsic bursting dynamics we are able to replicate specific in vivo results relating to the regulation of bursting by this feedback network, and able to examine the regulation of sensory coding by this feedback. The GABAA component of the inhibition is able to create a network mediated oscillation, which significantly deteriorates coding. The GABAB component, while unable to ameliorate the interference of the network oscillation, is able to restore the feature detection properties of the individual units such that the ability to accurately detect burst stimuli is improved. This may represent a mechanism for improving the detection of prey-like stimuli in the presence of conspecifics.

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Correspondence to W Hamish Mehaffey.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mehaffey, W.H., Maler, L. & Turner, R.W. Feedback modulation of intrinsic firing dynamics restores feature detection in electrosensory processing. BMC Neurosci 8, P53 (2007) doi:10.1186/1471-2202-8-S2-P53

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Keywords

  • Pyramidal Cell
  • Model Neuron
  • Feature Detection
  • Plausible Model
  • Feedback Modulation